SRB for Control of Inflammation and Joint Health

The Stabilized Rice Bran (SRB) is KEY to my “POWER DRINK” based detox program. Recent studies have documented a role for stabilized rice bran in treating diabetes and arthritis in addition to its detox benefits. Stabilized Rice Bran is available in the Longevity Plus product, Beyond Fiber. This product is a key part of my life time detoxification program. Beyond Fiber also includes Jerusalem Artichoke extract from Germany, as an advanced form of Inulin, which has a much larger molecular structure than FOS, which I do not use. This also lowers Candida count while supporting healthy flora as a vital probiotic. The product also includes EDTA, and with the stabilized rice bran, you have one of the most nutrient dense foods available anywhere. It includes gamma oryzanol and Octocosinol and beta sitosterol and inositol and other B Vitamins.  I enjoy my POWER DRINK twice daily, which also includes my Organic Best of Greens powder, Maca powder and BIOE’NR-G’Y C mixed in 8+ ounces of any healthy fluid.

Now we are learning that SRB not only acts as a great fiber when combined with the artichoke extract so you have the ideal ratio of soluble to insoluble fiber for optimal assistance with toxin removal but now you have documentation that you are also providing vital anti-inflammatory benefits. This research has documented that some of these benefits are because SRB inhibits several key inflammatory enzymes. Thus you now have scientific explanation for the reports in the literature about SRB being helpful in Diabetes and Arthritis, but now we have the mechanism of action for these benefits.
However, SRB in my mind is crucial to supporting healthy intestinal flora and thus in reducing leaky gut and lowering the tendencies to food sensitivities. If you treat everyone with a detox program, as I do, Beyond Fiber should be a standard part of your management of most patients. We have also seen research that SOLUBLE fiber can help carry out toxins so with a world of toxic patients, many of whom have excessive levels of inflammation, it seems that Beyond Fiber should be a part of many patients supplement program.
I usually start with small doses of even 1/2 tsp for a few days, as there will be some gas and stool changes in many at first, particularly if you are ingesting the SRB along with some of the other detox ingredients in my POWER DRINK.

If you believe, as I do, that most of us require a daily probiotic then with the SRB, you will be providing key PREBIOTIC support to whatever probiotic you choose. If you should also be lowering the total body burden of heavy metals, then using either Beyond Chelation-Improved alone or with the ZEOLITE products, there will be stool changes and some increased frequency and looseness to bowels for a time, from 2 weeks to 3 months depending on how aggressively you choose to increase the levels of the “power drink”. I usually want most patients over about 4+ weeks to have gradually increased their intakes of Fiber and other power drink ingredients to hopefully 1 level tsp of each. Then, over time raise that to a slightly heaping teaspoonful or more of all 4 ingredients. It is not essential to go to 1 tablespoon doses, as this is really a life time program and hurrying it along with higher dosages does not seem to be that useful.

Garry F. Gordon MD,DO,MD(H)
President, Gordon Research Institute
www.gordonresearch.com
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J Med Food. 2009 Jun;12(3):615-23.
http://www.ncbi.nlm.nih.gov/pubmed/19627211

Pro-inflammatory enzymes, cyclooxygenase 1, cyclooxygenase 2, and 5-lipooxygenase, inhibited by stabilized rice bran extracts.

Roschek B Jr, Fink RC, Li D, McMichael M, Tower CM, Smith RD, Alberte RS.
HerbalScience Group LLC, Naples, Florida 34110, USA.

Rice bran, the outer bran and germ of the kernel and a by-product of rice milling, is rich in phytonutrients but has been underutilized because of lipid content instability. New methods for the processing of rice bran have yielded a stabilized form that is increasingly used in foods and dietary supplements. Recent studies have documented a role for stabilized rice bran (SRB) in treating diabetes and arthritis, although little is known of the bioactive compounds that impart these health benefits. Here we characterize the chemical composition of three extracts of SRB and identify the functional bioactives contributing to the inhibitory properties against three key pro-inflammatory enzymes (cyclooxygenase [COX] 1, COX2, and 5-lipoxygenase [5-LOX]) that control the inflammatory cascade involved in impaired joint health, pain, and arthritis. One extract (SRB-AI) demonstrated significant COX1 and COX2 inhibitory activities with 50% inhibitory concentration (IC(50)) values for COX1 and COX2 of 305 and 29 microg/mL, respectively, but no 5-LOX inhibition. The second extract (SRB-AII) inhibited COX1, COX2, and 5-LOX with IC(50) values of 310, 19, and 396 microg/mL, respectively. The third extract (SRB-AIII), a blend of SRB-AI and SRB-AIII, inhibited COX1, COX2, and 5-LOX with respective IC(50) values of 48, 11, and 197 microg/mL. Analysis of the extracts by direct analysis in real time time of flight-mass spectrometry revealed that SRB-AI, SRB-AII, and SRB-AIII contain over 620, 770, and 810 compounds, respectively. Of these, 17 were identified as key bioactives for COX and/or LOX inhibition. These SRB extracts have applications for functional foods and dietary supplements for control of inflammation and joint health.

PMID: 19627211 [PubMed - in process]

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Tagged as: anti-inflammatory, Arthritis, Candida, detoxification, diabetes, EDTA chelation therapy, Food Allergies, heavy metals, inulin, jerusalem artichoke, leaky gut, prebiotics, probiotics, soluble fiber, stabilized rice bran, toxins, vitamin C, zeolite